David R. Emlet, PhD
Education & Training
BS, Biology, Dickinson College, 1990
PhD, Molecular Pharmacology and Structural Biology, Thomas Jefferson University, 2002
Post-doctoral Fellowship, Signal Transduction, Thomas Jefferson University, 2003
Research, Clinical & Academic Interests
- Molecular mechanisms and biological functions of the acute kidney injury biomarkers IGFBP7 and TIMP2
- Development of physiologically relevant two- and three-dimensional in vitro model systems of human kidney proximal and distal tubule epithelial cells
Wen X, Cui L, Morrisroe S, Maberry D, Emlet DR, Watkins SC, Hukriede NA, Kellum JA. A zebrafish model of infection-associated acute kidney injury. American Journal of Physiology-Renal Physiology. 2018.
Wenzel SE, Tyurina YY, Zhao J, St Croix CM, Dar HH, Mao G, Tyurin VA, Anthonymuthu TS, Kapralov AA, Amoscato AA, Mikulska-Ruminska K, Shrivastava IH, Kenny EM, Yang Q, Rosenbaum JC, Sparvero LJ, Emlet DR, Wen X, Minami Y, Qu F, Watkins SC, Holman TR, VanDemark AP, Kellum JA, Bahar I, Bayır H, Kagan VE . PEBP1 wardens ferroptosis by enabling lipoxygenase generation of lipid death signals. Cell. 2017 Oct 19;171(3):628-41.
Emlet DR, Pastor-Soler N, Marciszyn A, Wen X, Gomez H, Humphries IV WH, Morrisroe S, Volpe JK, Kellum JA. Insulin-like growth factor binding protein 7 and tissue inhibitor of metalloproteinases-2: differential expression and secretion in human kidney tubule cells. American Journal of Physiology-Renal Physiology. 2016 Dec 21;312(2):F284-96.
Emlet DR, Shaw AD, Kellum JA. Sepsis-associated AKI: epithelial cell dysfunction. InSeminars in nephrology 2015 Jan 1 (Vol. 35, No. 1, pp. 85-95). WB Saunders.
Faculty member, Center for Critical Care Nephrology, CRISMA Center
Director, Center for Critical Care Nephrology Tissue Bank, Pittsburgh Center for Kidney Research
Chief of Operations, 28th Combat Aviation Brigade, OIF 09-11
Dana Internship, Dickinson College, 1988-1989
Bronze Star Medal, 1990-2013
Meritorious Service Medal (2), 1990-2013