Xiaoyan Wen, MD, MS

Research Assistant Professor, Critical Care Medicine

Contact Information

wenx[at]upmc.edu
412-383-4205

Administrative Contact:
Karen Nieri

Education & Training

MS, Nephrology, Peking Union Medical College, 1999
MD, China Medical College, 1994

Research, Clinical & Academic Interests

  • Renal cell responses (cell cycle arrest) secondary to initial injury
  • Inflammatory cell (TH cell, Macrophage) phenotype transition and their roles in kidney injury and recovery
  • Epithelial cell EMT in the process of fibrosis
  • The associations between expression of biomarker with AKI-outcome


Wen X, Wan X, Zhang J, Frank A, Kellum JA. Enhanced regulatory T cell activation leads to renal protection at the expense of immune suppression in a mouse model of severe sepsis. Journal of immunology research (in press).

Wen X, Cui L, Morrisroe S, Maberry D Jr, Emlet D, Watkins S, Hukriede NA, Kellum JA. A zebrafish model of infection - associated acute kidney injury. Renal physiology. 2018; 315(2): F291 - F299.

Murugan R, Wen X, Shah N, Lee M, Kong L, Pike F, Keener C , Unruh M, Finkel K, Vijayan A, Palevsky PM, Paganini E, Carter M, Elder M, Kellum JA; Biological Markers for Recovery of Kidney (BioMaRK) Study Investigators. Plasma inflammatory and apoptosis markers are associated with dialysis dependence and death among critically ill patients receiving renal replacement therapy. Nephrol Dial Transplant. 2014 Oct;29(10):1854 - 64. doi: 10.1093/ndt/gfu051. Epub 2014 Mar 11.

Wen X, Peng Z, Li Y, Wang H, Bishop JV, Chedwick LR, Singbartl K, Kellum JA. One dose of cyclosporine A is protective at initiation of folic acid - induced acute kidney injury in mice. Nephrol Dial Transplant. 2012 Aug;27(8):3100 - 9. doi: 10.1093/ndt/gfr766. Epub 2012 Jan 31.

► Full listing on Pub Med

Member, Center for Critical Care Nephrology
Member, CRISMA Center