Nahmah Kim-Campbell, MD, MS Awarded K23 Grant to Study Renal Injury After Cardiopulmonary Bypass

Assistant Professor Nahmah Kim-Campbell, MD, MS was awarded a K23 grant entitled “Mechanisms of Cell-Free Plasma Hemoglobin-Mediated Renal Injury After Cardiopulmonary Bypass” from the Eunice Kennedy Shriver National Institute of Child Health & Human Development. The project will investigate the role of cell-free plasma hemoglobin (PHb) in acute kidney injury (AKI) in children undergoing cardiopulmonary bypass (CPB) as well as in an experimental model of extracorporeal therapy in order to identify clinically meaningful therapies.

“Extracorporeal therapies are some of the greatest advances in pediatric critical care, yet they are often associated with unfavorable outcomes, such as AKI” said Dr. Kim-Campbell, who is a critical care attending in the Pediatric ICU at UPMC Children’s Hospital of Pittsburgh. “AKI is incompletely understood and particularly problematic since it is associated with mortality and prolonged ICU and hospital length of stay.”

She explained that PHb can be produced in large quantities during CPB and other forms of extracorporeal therapy. Based on her preliminary data, the project focuses on the idea that PHb and PHb-haptoglobin complexes have peroxidase activity that consumes reductants or antioxidants—such as ascorbate, glutathione, and nitric oxide—and also leads to the production of end products of lipid oxidation. Ultimately, the study will lead to a greater ability to identify risk factors of PHb-mediated renal injury after CPB and illuminate the mechanisms by which PHb may contribute to AKI.

Dr. Kim-Campbell has a mentoring team comprised of internationally recognized investigators including Hülya Bayır, MD and John Kellum, MD from the Department of Critical Care Medicine. Additional members of her K committee include Patrick Kochanek, MD, director of the Safar Center for Resuscitation Research; Carlton Bates, MD from the Division of Pediatric Nephrology; and Kristine Ruppert, DrPH from the School of Public Health at the University of Pittsburgh.

Dr. Kim-Campbell holds a BA from the University of Pennsylvania and an MD from the University of Pittsburgh. She completed her Pediatric residency at Children’s National Medical Center, fellowship in Pediatric Critical Care Medicine at UPMC Children’s Hospital of Pittsburgh, and an MS in Clinical Research at the University of Pittsburgh. She is an assistant professor of Critical Care Medicine and Pediatrics.