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Clinical Research, Investigation, and Systems Modeling of Acute illness (CRISMA) Center

The CRISMA Center, a clinical, translational and health services research group conducting cutting-edge research into the optimal care of the critically ill, was founded in 2001 concurrent with the founding of the CCM Department. By its very nature, the CRISMA Center is multidisciplinary. Research is performed by world class teams organized into five programs of research: Clinical Epidemiology, Ethics and Decision Making, Health Policy and Management, Systems Medicine, and the Center for Critical Care Nephrology. These programs receive support services through four core teams: Administration, Biostatistics and Data Management, Molecular Biology, and Long-Term Follow-Up. Though organized into five programs of research, the center was designed to foster collaboration. Researchers not only cooperate extensively and across program lines within CRISMA and intramurally at Pitt, but also frequently collaborate with external constituents, including other research institutions and industry partners.

Demonstrating that CRISMA is solidly at the forefront of critical care research, Center researchers garner a great deal of national and international recognition. In 2015, Director Derek C. Angus was the recipient of a Top 10 Clinical Research Achievement Award from the Clinical Research Forum. He was nominated for his role as lead author of the ProCESS Investigators’ paper, “A Randomized Trial of Protocol-Based Care for Early Septic Shock,” published in the New England Journal of Medicine on May 1, 2014. CRISMA colleagues John Kellum, David Huang, and Francis Pike were co-authors on the paper.

CRISMA Center investigators are not merely publishing in high-impact journals, among them the New England Journal of Medicine, JAMA, Lancet, and Critical Care Medicine, but further their research is widely disseminated. Notably, Derek C. Angus’ article, “Severe sepsis and septic shock,” originally published in the August 29, 2013 issue of the New England Journal of Medicine, was the Most Read Paper in 2014 according to the medical journal database, QxMD. Moreover, in 2014 three of the most discussed and downloaded articles from the journal Critical Care included major contributions by CRISMA researchers.

CRISMA investigators have a long history mentoring clinical and research fellows, particularly physicians and scientists interested in pursuing an academic career in critical care medicine. Most CRISMA research fellows simultaneously complete advanced training in clinical and health services research through either the Masters in Public Health (MPH) program at the Graduate School of Public Health, the Clinical Research Training Program, or the Clinician Educator Training Program. Former trainees have moved on to very successful careers in academic research.

CRISMA Center Publications from Current Academic Year

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