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STOPGAPS: Epigenetics and Outcomes in Pediatric Sepsis

Co-PIs: Tom Shanley University of Michigan, Jerry Zimmerman Seattle Children’s, Michael J Bell and Joseph A Carcillo, University of Pittsburgh

Funding: National Institutes of Child Health and Development

This study evaluates the contribution of hypoxia-ischemia related brain injury and epigenetic changes in IL-10 to subsequent death and the development of new onset functional morbidity in children after sepsis.  This study asks the question whether the combination of ischemia and inflammation leads to epigenetic changes which render the host to be unable to have make a full recovery.  If parents agree, children with sepsis will have non-invasive NIRS monitoring and blood sampling performed, and then be asked to have long term developmental testing performed by phone.  The study expects to recruit 400 patients over a two year period.  This study will elucidate the role of epigenetics in long term disability of sepsis.