PI: Derek Angus, MD
Funding: NIH P50GM076659 (Project period: 9/22/2006 to 8/31/2013)
Severe sepsis is the syndrome of acute organ dysfunction secondary to infection. It affects 750,000 Americans each year, with a mortality of 30%. Despite considerable understanding of the pathophysiology of sepsis, current efforts to improve care are hampered by limited empiric data regarding the amount and timing of sepsis therapies. This stands in stark contrast to other acute conditions such as acute coronary syndromes, where standardized, prompt, rigorous care has dramatically improved outcome and paved the way for better clinical and translational research. We amassed for this Center proposal a multidisciplinary group of investigators and consortium of leading institutions. Our goal was to address the overarching hypothesis that there are ‘golden hours’ in the initial management of sepsis and septic shock where prompt, rigorous, standardized care can reduce unwanted downstream consequences and improve clinical outcomes.