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Predicting Risk of Pneumonia in the General Population

PI: Sachin Yende, MD

Co-Investigator:  Derek C. Angus, MD

Funding: NIGMS K23GM083215 (Project period: 9/2/08 to 8/31/14)

Community-acquired pneumonia is the leading cause of hospitalization in developed countries. To date, there is no risk prediction models to determine who develops pneumonia and why.

Aim #1 will develop and validate a model for community-acquired pneumonia (CAP) susceptibility. This proposal will combine 3 population-based cohorts in the US: Atherosclerosis Risk in Communities (ARIC) study, Cardiovascular Health Study (CHS), and Health, Aging, and Body Composition (Health ABC) study. Together these cohorts include over 20,000 subjects with over 10 years of follow-up. We have identified pneumonia events and will determine role of clinical factors, genetic markers, and biomarkers.

Aim #2 will explore the role of neutrophil function in CAP susceptibility in a small subset of patients who have developed pneumonia.