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Poly(ADP-Ribose) Polymerase and Brain Injury

PI: Robert Clark, MD

Funding: National Institute of Neurologic Diseases and Stroke P01NS030318

Energy failure contributes importantly to cell death after traumatic brain injury. Recent studies suggest that a key participant in cellular energy failure is the abundant enzyme poly(ADP-ribose) polymerase (PARP) which is present in all cells. We aim to establish the role of PARP in traumatic brain injury. Pharmacologic inhibition of PARP may prove to be a powerful and clinically relevant means of reducing energy failure and cell death, and thereby improving neurologic outcome after traumatic brain injury.