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Cost of Surviving Sepsis

PI: A. Murat Kaynar

Pitt-affiliated Co-Is: Veli Bakalov, Derek Angus, Steven Shapiro

Grant information: R01HL126711 NIH/NHLBI "Combined Viral and Bacterial Infection and Zinc Homeostasis in Distal Lung" (Project period: 4/1/2015 – 3/31/2020)

Related Publications: Cost of surviving sepsis: a novel model of recovery from sepsis in Drosophila melanogaster. Intensive Care Med Exp. 2016 Dec;4(1):4.

Sepsis is a significant global health problem, with more than 20 million patients affected annually and a direct economic costs calculated in $17 billion. This disease imposes additional costs to the society, families, and patients, including lost days of work, absence from school, and long-term disabilities. In recent years, a significant reduction in short-term mortality rates of patients with sepsis syndrome resulted in an increasing population of survivors. Sepsis survivors frequently incur a dramatic decline in functional capacity and quality of life that can persist for years and carry a higher long-term risk of subsequent morbidity and mortality compared to age-matched controls, such as increased rates of cardiovascular events, new infections, cancer, and neurocognitive or muscular dysfunction, metabolic disturbances, and shortened lifespan. Our group showed such changes in clinical cohorts and the literature suggests that sustained inflammation is the driving force behind these metabolic and functional changes during the recovery from sepsis.

We recently developed a Drosophila model of sepsis to explore inflammation, functional impairment, metabolic derangements, and lifespan in the recovery phase of sepsis.