Associate Professor of Critical Care Medicine, Mathematics and Industrial Engineering
Director, CRISMA Systems Medicine Program
Medical Director, Center for Inflammation and Regenerative Modeling
The Systems Medicine Program (CRISMA) seeks to explore the intersection of advanced quantitative methods and bedside care with the ultimate vision of leveraging mathematical, computational and engineering expertise to deliver improved personalized care to the critically ill. Fundamental to this goal is the belief that such work is best accomplished by scientists that can bridge cultural differences between clinical medicine and quantitative sciences.
The systems medicine program is necessarily transdisciplinary and maintains a diversified portfolio of projects. Within CRISMA, the program has overlapping interests and shares resources with The Center for Critical Care Nephrology and the Health Policy & Management Programs.
These projects are supported through federal agencies (NIGMS, NIAID, NLM, NSF, NIDDK, NHLBI) and through industry collaborations. The genesis of the systems medicine program was itself transdisciplinary through a privileged collaboration with investigators from the Departments of mathematics (Carson Chow) and surgery (Yoram Vodovotz) supported by an exploratory grant, “Modeling the acute inflammatory response” (R01, 2002-07). This project was an early contribution to the NIH Roadmap Initiative seeking the integration of quantitative methods and systems approaches to improving patient care. Since then, our portfolio and resources have expanded considerably with a variety of collaborations, locally, nationally and internationally.