Matthew Neal, MD, Assistant Professor of Surgery and Critical Care Medicine, was recently awarded several new research achievements. The first is a patent (US patent 9,072,760) entitled, “Toll-like receptor 4 (TLR4) inhibitors for the treatment of human infectious and inflammatory disorders.” This patent stems from research that Neal did in drug development along with the Drug Discovery Institute at the University of Pittsburgh. Co-inventors on the patent include Peter Wipf, Distinguished University Professor, Department of Chemistry, University of Pittsburgh; David Hackam, Professor of Surgery, Johns Hopkins University; and Chhinder Sodhi, Assistant Professor of Surgery, Johns Hopkins University.
In addition, Neal was also recently awarded a Pilot Project Program in Hemostasis and Vascular Biology (P3HVB) grant from the Vascular Medicine Institute (VMI), for a project entitled, “Platelet derived HMGB1 regulates thrombosis and organ injury following trauma and hemorrhagic shock.” The grant will be direct support for mechanistic basic science investigations into the acute coagulopathy of trauma and seeks to devise a therapeutic strategy based on novel drug targeting to platelet dysfunction. As part of this award, Neal was nominated as a Member of the VMI.
Neal, who completed a surgical critical care fellowship in our Multidisciplinary Critical Care Training Program (MCCTP) in 2015, operates a lab in the Department of Surgery, which focuses on the mechanisms of organ failure and coagulopathy following trauma and hemorrhage. Neal is also an Attending Surgeon in the Division of Trauma and Acute Care Surgery, UPMC.