Earlier this year, a figure from an article co-authored by several faculty in the Department of Critical Care Medicine was featured on the cover of an issue of Shock: Injury, Inflammation, and Sepsis: Laboratory and Clinical Approaches.
The figure, which was used to illustrate alterations in inflammation, microcirculatory flow and its association to tubular epithelial injury caused by sepsis, appeared in the article, “A Unified Theory of Sepsis-Induced Acute Kidney Injury: Inflammation, Microcirculatory Dysfunction, Bioenergetics, and the Tubular Cell Adaptation to Injury,” co-authored by Hernando Gomez, Can Ince, Daniel De Backer, Peter Pickkers, Didier Payen, John Hotchkiss, and John A. Kellum.
The figure represents the hypothetical interaction between two mechanisms that are implicated in the development of sepsis-induced AKI—microvascular dysfunction, and the adaptive response of the renal tubular epithelial cell to the injury. The interaction between these mechanisms is at the heart of Dr. Gomez’s K12 grant.
The article was published in Volume 41, Issue 1 (January 2014) of the journal, was highlighted by the Editor-in-Chief of Shock as being of particular interest, and was the featured article in the “Hot Topics in Critical Care” section by Wolters Kluwer.
Dr. Hernando Gomez is an Assistant Professor of Critical Care Medicine in the Department of Critical Care Medicine, University of Pittsburgh.
Dr. John Hotchkiss is an Associate Professor of Critical Care Medicine and Associate Professor of Medicine in the Department of Critical Care Medicine, University of Pittsburgh.
Dr. John A. Kellum is a Professor of Critical Care Medicine and Professor of Medicine (Bioengineering and Clinical & Translational Science) in the Department of Critical Care Medicine, University of Pittsburgh. Dr. Kellum is also the Director of the Center for Critical Care Nephrology and the Director for the Center for Assistance in Research using eRecord (CARe).