Research Assistant Professor, Center for Critical Care Nephrology, CRISMA Center
David R. Emlet, PhD, is a Research Assistant Professor in the Center for Critical Care Nephrology, CRISMA, in the Department of Critical Care Medicine. Dave is a molecular/cell biologist with expertise in signal transduction research. He has established an in vitro model systems research program in the Center to investigate the mechanisms of acute kidney injury (AKI) at the molecular and cellular level. These systems serve as stand-alone tools for discovery as well as support and compliment the established animal models in the Center. His current area of focus is on elucidating the roles and functions of the early AKI biomarkers IGFBP7 and TIMP2 in human kidney epithelial cells of proximal and distal tubule origin.
Education & Training
|Dickinson College, Carlisle, PA||B.S.||1990||Biology|
|Army Reserve Officer Training Corps||Commissioned Officer||1990||Aviation|
|Army Aviation School, Fort Rucker, AL||Army Aviator||1992||Rotary-wing Aviation|
|Thomas Jefferson University, Philadelphia, PA||Ph.D.||2002||Molecular Pharmacology and Structural Biology|
|Thomas Jefferson University, Philadelphia, PA||Postdoctoral||2003||
My expertise is in cellular and molecular biology, with an emphasis on signal transduction. I have over 15 years of PhD experience, and have contributed significantly to a number of successful projects and grant applications. In 2014, I was recruited as a Research Associate by Dr. John Kellum into the Center for Critical Care Nephrology to develop an in vitro model systems program to research acute kidney injury, and I was promoted to Research Assistant Professor in February 2017. I established an in vitro studies research program from the ground up, and have established and maintained a University approved collaboration with the Center for Organ Recovery and Education (CORE) for the receipt and processing of human kidneys for research. Since July 2014 I have received and processed 39 human kidney samples (68 whole human kidneys) for current research and collaboration, as well as for archiving for future in vitro, proteomic, and genomic studies. I have conceived and lead or performed all of the molecular and cellular based studies that have resulted in our first publication in 2016. Additionally, by establishing and maintaining this human kidney tissue/cell resource, I have established no less than six separate collaborations for research that cross a gamut of kidney related diseases.