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Ali Al-Khafaji, MD, MPH, FACP, FCCP

Professor of Critical Care Medicine

Medical Director, Transplant Intensive Care Unit, UPMC Montefiore

412.647.9238
Admin Assistant: Joanne Woodson
412.647.8499

Education & Training

Degree

Year

Field

Al-Mustansiriya University, Baghdad, Iraq

 MD

 1993

Medicine

London School of Hygiene and Tropical
Medicine, London, United Kingdom

 MPH

 2004

Health Services /
Systems Research

Chase Farm Hospital, London England

 Residency

 1994

Medicine

The Mercy Hospital of Pittsburgh, PA

 Residency

 1999

Medicine

Dartmouth Medical School

 Fellowship

  2001

Critical Care Medicine

University College London, London, UK

 Fellowship

  2005

Anesthesia and Critical
Care Medicine


Administrative Title

Professor of Critical Care Medicine

Medical Director, Transplant Intensive Care Unit

 

Research

Federal Research Grants and Clinical Trials:

  • VTI 308: A Randomized, Open-label, Multicenter, Controlled, Pivotal Study to Assess Safety and Efficacy of ELAD® in Subjects with Alcohol-Induced Liver Decompensation (AILD). Role: Principal Investigator. The primary objective of the study is to evaluate safety and efficacy of ELAD® with respect to overall survival of subjects with a clinical diagnosis of alcohol-induced liver decompensation (AILD) through at least Study Day 91.
  • Remodulin Study:  Single center, randomized, double-blind parallel placebo-controlled study of the safety and efficacy of perioperative Remodulin in Orthotopic liver transplant recipients. Role: Co-I. University of Pittsburgh
  • Survey of inpatient capabilities at Matibabu Hospital PRO14090192. The goal of this project was to assess the inpatient capabilities of Matibabu Hospital, Kenya, through a survey of health care worker backgrounds, training, perceptions of facility needs, and capabilities of the facility.
  • Retrospective Study of BUN/Cr ratio as Prognostic Factor for Liver Failure after Acetaminophen Toxicity. PRO12110307, Role Co-I. The purpose of this study is to determine if a BUN:Cr ratio could be used as a prognostic marker for death or patients requiring liver transplantation after an acetaminophen overdose.
  • Monitoring Organ donors to Improve Transplantation Results (MOnIToR). Role: Co- PI. This project is aimed at improving transplantation outcomes by reversing acute organ dysfunction in the donor. Our efforts to date have culminated in a consortium of nine Organ Procurement Organizations that are engaged in research to improve organ function by use of targeted resuscitation using functional hemodynamic monitoring.
  • Noninvasive assessment of hepatic function following transplant. Role: PI. This is a single center study of the use of non-invasive measures of hepatic performance using ICG clearance coupled with routine measures of hepatocellular function on post-operative liver transplant patients to identify early graft rejection, ischemic injury and its recovery.
  • Identification and Validation of Biomarkers of Acute Kidney Injury Recovery – Ruby Study. Role: PI
  • ELAD – Extracorporeal liver assist device for alcohol induced liver decompensation. Role: PI. A randomized, open-label, multicenter, controlled study to assess safety and efficacy of ELAD® in subjects with alcohol induced Liver decompensation (AILD) – VTI-208.
  • Outcome of Variceal Bleeding in our Institution- TIPS Vs Band ligation. PRO13110004, Role Co-I. This study will assess the prevalence of patients undergoing TIPS for acute variceal bleeding as opposed to band ligation and their outcomes through the use of retrospective medical record data
  • Clinical and Predictive Assessment of Abdominal Transplant Recipients and Donors and Potential Transplant Recipients with Chronic Disease. PRO13060220, Role Co- I. The objective is to evaluate past and present outcomes of end stage organ failure with transplantation and to determine new methods and treatments for improving these outcomes. Electronic clinical records of patients seen by the Transplant team will be reviewed in order to discover how to use clinical information to diagnose and predict outcomes of patients with end stage organ failure awaiting or treated with transplant and evaluate new forms of treatment to improve these outcomes.
  • Investigation into the predictors of post-operative acute kidney injury and acute renal failure in patients undergoing orthotopic liver transplantation. Role:  Co-PI
  • Principal Investigator (UPMC Site) for the Clinical Protocol AST-111 - Evaluation of Novel Biomarkers from Acutely Ill Patients at Risk for Acute Kidney Injury
  • Dr. Al-Khafaji is also an investigator on the following studies:
    • Outcome Study of Jehovah Witness Orthotopic Liver Transplantation (OLT) Recipients
    • Clinical and Predictive Assessment of Abdominal Transplant Recipients and Donors and Potential Transplant Recipients with End Stage Organ Disease
    • A pilot study evaluating thrombin generation and its correlation with the International Normalized Ratio (INR) in the setting of cirrhosis versus patients receiving Vitamin-K antagonist (VKA)
    • Predictors of Acute Kidney Injury and Acute Renal Failure after Orthotopic Liver Transplantation 

 

Publications (2014–16)

  • Gunnerson KJ, Shaw AD, Chawla LS, Bihorac A, Al-Khafaji A, Kashani K, Lissauer M, Shi J, Walker MG, Kellum JA; Sapphire Topaz investigators. TIMP2•IGFBP7 biomarker panel accurately predicts acute kidney injury in high-risk surgical patients. J Trauma Acute Care Surg. 2016 Feb;80(2):243-9. PMID: 26816218
  • Yang ZJ, Sheth SH, Smith CH, Schmotzer AR, Lippello AL, Al-Khafaji A, Chopra KB, Smith RE. Plasma from chronic liver disease subjects exhibit differential ability to generate thrombin. Blood Coagul Fibrinolysis. 2015 Oct;26(7):844-7. PMID: 26200653
  • Hilmi IA, Damian D, Al-Khafaji A, Sakai T, Donaldson J, Winger DG, Kellum JA. Acute kidney injury after orthotopic liver transplantation using living donor versus deceased donor grafts: A propensity score-matched analysis. Liver Transpl. 2015 Sep;21(9):1179-85. PMID: 25980614
  • Al-Khafaji A, Nadim MK, Kellum JA. Hepatorenal Disorders. Chest. 2015 Aug;148(2):550-8. Review. PMID: 25811649
  • Hilmi IA, Damian D, Al-Khafaji A, Sakai T, Donaldson J, Winger DG, Kellum JA. Acute kidney injury after orthotopic liver transplantation using living donor versus deceased donor grafts: A propensity score-matched analysis. Liver Transpl. 2015 May 15.  PMID: 25980614.
  • Al-Khafaji A, Elder M, Lebovitz DJ, Murugan R, Souter M, Stuart S, Wahed AS, Keebler B, Dils D, Mitchell S, Shutterly K, Wilkerson D, Pearse R, Kellum JA. Protocolized fluid therapy in brain-dead donors; the multicenter randomized MOnIToR trial. Intensive Care Med. 2015 March; 41(3); 418-26. PMID: 25583616. PMCID: PMC4351113.
  • Hilmi IA, Damian D, Al-Khafaji A, Planinsic R, Boucek C, Sakai T, Chang CC, Kellum JA. Acute kidney injury following orthotopic liver transplantation: Incidence, risk factors and effects on patient and graft outcomes. Br J Anaesth. 2015 Feb. PMID: 25673576.
  • Bihorac A, Chawla LS, Shaw AD, Al-Khafaji A, Davison DL, Demuth GE, Fitzgerald R, Gong MN, Graham DD, Gunnerson K, Heung M, Jortani S, Kleerup E, Koyner JL, Krell K, Letourneau J, Lissauer M, Miner J, Nguyen HB, Ortega LM, Self WH, Sellman R, Shi J, Straseski J, Szalados JE, Wilber ST, Walker MG, Wilson J, Wunderink R, Zimmerman J, Kellum JA.  Validation of cell-cycle arrest biomarkers for acute kidney injury using clinical adjudication.  Am J Respir Crit Care Med. 2014 Apr 15;189(8):932-9.  PMID: 24559465.
  • Harika R, Bermas K, Hughes C, Al-Khafaji A, Iyer M, Wallace DJ. Cardiac arrest after liver transplantation in a patient with takotsubo cardiomyopathy. Br J Anaesth 2014. Mar; 112(3): 594-5.  PMID:24535530

View all of Dr. Al-Khafaji's publications on PubMed.